Poster 122: RANTES/CCL5 and BFGF Concentration at the Time of Surgery Can Predict Postoperative Stiffness in Patients Undergoing ACLR

Objectives: Patients undergoing anterior cruciate ligament reconstruction have been shown to be at risk for postoperative arthrofibrosis. Diagnostic biomarkers associated with development of stiffness are unknown. The objective this study is identify found in the synovial fluid time surgery that arthrofibrosis a cohort patients Methods: were prospectively enrolled. Synovial was collected OR prior surgical incision. A requiring manipulation under anesthesia or lysis adhesions identified. Matching case controls performed using 1:2 pair matching algorithm. Clinical factor-adjusted single biomarker and multivariable models used assess association MUA/LOA. Results: total 11 (n = 3 male, n 8 female) ACLR met inclusion criteria, matched 21 6 15 no significant differences age, sex, smoking history, days from injury surgery. Levels RANTES significantly higher cases versus (694.20 [214.75 - 3428.79] vs. 113.04 [32.81 517.91]; p=0.034). IL-IRA, bFGF, greatest predictive value by final stepwise logistic regression model. Independent predictors increased after included (OR [95% CI]) (2.28 [1.29 – 5.37]; p=0.019) bFGF (1.91 [1.07 3.99]; p=0.047) according Only statistically predictor developing (2.59 [1.26-9.07]; p=0.046). Conclusions: Higher concentrations ACLR. IL-6, VEGF, TIMP1, IL-1RA, MMP3, MCP-1, MIPB not